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4-Fluorococaine (4-FC)

4′-Fluorococaine is a tropane derivative drug which is a synthetic analogue of cocaine. Unlike related compounds such as the corresponding 4′-fluorophenyltropane derivative CFT and the 2′-hydroxy analogue salicylmethylecgonine, 4′-fluorococaine has only around the same potency as cocaine as an inhibitor of dopamine reuptake, but conversely it is a much stronger serotonin reuptake inhibitor than cocaine, resulting in a significantly altered pharmacological profile in animal studies.

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Description

4′-Fluorococaine

4′-Fluorococaine is a tropane derivative drug which is a synthetic analogue of cocaine. Unlike related compounds such as the corresponding 4′-fluorophenyltropane derivative CFT and the 2′-hydroxy analogue salicylmethylecgonine, 4′-fluorococaine has only around the same potency as cocaine as an inhibitor of dopamine reuptake, but conversely it is a much stronger serotonin reuptake inhibitor than cocaine, resulting in a significantly altered pharmacological profile in animal studies.

It inhibits a reuptake of dopamine, but is a much stronger serotonin reuptake inhibitor. This has lead to various results in animal studies. 4Fluorococaine has the same potential as cocaine, but may be much more powerful as a result of the stronger reuptake of serotonin. 4Fluorococaine can therefor not be compared to CFT or 2′-hydroxy analogue salicylmethylecgonine
Systematic (IUPAC) name
methyl (1R,2R,3S,5S)-3-(4-fluorobenzoyloxy)-8-methyl-8-azabicyclo[3.2.1] octane-2-carboxylate

Clinical data
Pregnancy cat.?
Legal status?
Identifiers
CAS number 134507-62-3
ATC code ?
PubChem CID 126112
ChemSpider 112124 Yes
Chemical data
Formula C17H20FNO4
Mol. mass 321.343

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